"His fracture has been healing well and he has been able to do some high quality training over the past week."
Reef said Matthews would be supported by a strong team, which included reigning Giro d'Italia champions Tom Dumoulin.
The Dutchman crashed out of the Tirreno Adriatico, but will work for the Canberran as he continued his preparation to defend his pink jersey.
"Tom ... will be one of the key support riders for the final. Roy [Curvers] is our road captain and starts his seventh Milan-San Remo, so we have an experienced guy to lead the team," Reef said.
"After a really tough week, we remain positive and look forward to the first Monument of the season."