Updated: 09:26, Tuesday December 10, 2013
Vitamin D may combat multiple sclerosis (MS) by blocking the migration of destructive immune cells to the brain, new research suggests.
The findings may help explain anecdotal reports of the 'sunshine vitamin' preventing or easing symptoms, say scientists.
MS is known to be more prevalent in parts of the world furthest from the equator, where there is less sunshine to trigger production of vitamin D in the skin.
The disease is caused by the body's own immune defences damaging myelin, a fatty insulating sheath that surrounds nerve fibres and is vital to the proper transmission of nerve signals.
Destruction of myelin leads to symptoms ranging from numbness to blurred vision and paralysis.
'With this research, we learnt vitamin D might be working not by altering the function of damaging immune cells but by preventing their journey into the brain,' said lead scientist Dr Anne Gocke, from Johns Hopkins University School of Medicine in the US.
In a person with MS, immune system cells called T-cells are primed to travel out from the lymph nodes and seek and destroy myelin in the central nervous system.
Dr Gocke's team of researchers simultaneously gave mice the rodent form of MS and a high dose of vitamin D. They found that disease symptoms were suppressed in the animals.
While large numbers of T-cells were found in the bloodstreams of the mice, very few were detected in their brains and spinal cords.
Once vitamin D was withdrawn from the mice, MS flare-ups occurred very quickly, said the researchers, whose findings appear in the journal Proceedings of the National Academy of Science.
A clinical trial testing the effect of vitamin D supplements on patients with MS is currently under way at Johns Hopkins University.