Carlton's worst fears for their AFLW skipper Brianna Davey were realised when scans confirmed she ruptured her ACL on Friday night and would need a knee reconstruction.
The 23-year-old defender suffered the injury with less than five minutes of the game remaining and was carried off the ground on a stretcher in agony.
Davey flew home with the team but received confirmation of the injury and will have surgery this month.
Carlton football manager Andrew McKay said he knew as soon as Davey went down in pain the injury was serious and the club would support her in the rehabilitation process.
Davey is the second AFLW player to suffer damage to her ACL in the first five games of the season.
In better news for the Blues, the damage star forward Tayla Harris did to her left shoulder when applying the final tackle of the game may not be as bad as first thought.
Harris nestled her shoulder in her jumper as she sung the song at the end of the game and looked close to tears as she headed to the rooms fearing the worst.
The Blues will monitor her progress ahead of next week's game against her former club, the Brisbane Lions.
The Giants also had their own injury concerns with Britt Tully suffering an AC sprain in the first half of the game and was due to have scans late on Saturday to determine the extent of the injury.