Irish Derby winner Latrobe will battle Saturday's VRC Derby winner Extra Brut in the Mackinnon Stakes at Flemington.
It is the first time the VRC Derby winner has backed up in the weight-for-age classic in the same year with the opportunity only arising after the raced was moved to the final Saturday of the Flemington carnival in 2016.
The previous two VRC Derby winners Ace High (2017) and Prized Icon (2016) were sent for a spell immediately after their wins in the three-year-old classic.
Ace High ran in Tuesday's Melbourne Cup and Prized Icon, who has not won a race since her Derby win, will also run in the Mackinnon Stakes on Saturday.
Latrobe, who arrived in January 2015, eight months before Extra Brut was born in September 2015, is trained by last year's Melbourne Cup winning trainer Joseph O'Brien.